The yeast protein kinase Mps1p is required for assembly of the integral spindle pole body component Spc42p.

doi:10.1083/jcb.200111025

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Article

The yeast protein kinase Mps1p is required for assembly of the integral spindle pole body component Spc42p.

The Journal of cell biology - 4 Feb 2002

Castillo Andrea R, Meehl Janet B, Morgan Garry, Schutz-Geschwender Amy, Winey Mark

Abstract excerpt

Saccharomyces cerevisiae MPS1 encodes an essential protein kinase that has roles in spindle pole body (SPB) duplication and the spindle checkpoint. Previously characterized MPS1 mutants fail in both functions, leading to aberrant DNA segregation with lethal consequences. Here, we report the identification of a unique conditional allele, mps1-8, that is defective in SPB duplication but not the spindle checkpoint....

Topics

Alleles
Amino Acid Sequence
Centrosome
Cytoskeletal Proteins
Fluorescent Antibody Technique
Gene Dosage
Genes, cdc
Kinetochores
Microscopy, Electron
Mitosis
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphoproteins

Phosphorylation

Protein Serine-Threonine Kinases

Protein Structure, Tertiary

Protein-Tyrosine Kinases

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 11827982
DOI: 10.1083/jcb.200111025
PMCID: PMC2173341

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11827982-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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