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Article

Key phosphorylation events in Spc29 and Spc42 guide multiple steps of yeast centrosome duplication.

Molecular biology of the cell - 15 Sept 2018

Jones Michele Haltiner, O'Toole Eileen T, Fabritius Amy S, Muller Eric G, Meehl Janet B, Jaspersen Sue L, Winey Mark

Abstract excerpt

Phosphorylation modulates many cellular processes during cell cycle progression. The yeast centrosome (called the spindle pole body, SPB) is regulated by the protein kinases Mps1 and Cdc28/Cdk1 as it nucleates microtubules to separate chromosomes during mitosis. Previously we completed an SPB phosphoproteome, identifying 297 sites on 17 of the 18 SPB components. Here we describe mutagenic analysis of...

Topics

Alleles
Centrosome
Cytoskeletal Proteins
Microtubule-Associated Proteins
Models, Biological
Mutation
Phosphoproteins
Phosphorylation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Spindle Pole Bodies

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Identifiers

PMID: 30044722
DOI: 10.1091/mbc.E18-05-0296
PMCID: PMC6249810

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