Article
Cdc28/Cdk1 regulates spindle pole body duplication through phosphorylation of Spc42 and Mps1.
Developmental cell - 1 Aug 2004
Jaspersen Sue L, Huneycutt Brenda J, Giddings Thomas H, Resing Katheryn A, Ahn Natalie G, Winey Mark
Abstract excerpt
Duplication of the Saccharomyces cerevisiae spindle pole body (SPB) once per cell cycle is essential for bipolar spindle formation and accurate chromosome segregation during mitosis. We have investigated the role that the major yeast cyclin-dependent kinase Cdc28/Cdk1 plays in assembly of a core SPB component, Spc42, to better understand how SPB duplication is coordinated with cell cycle progression. Cdc28 is...
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