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Article

Characterization of the chemokine CXCL11-heparin interaction suggests two different affinities for glycosaminoglycans.

The Journal of biological chemistry - 4 Jun 2010

Severin India C, Gaudry Jean-Philippe, Johnson Zoë, Kungl Andreas, Jansma Ariane, Gesslbauer Bernd, Mulloy Barbara, Power Christine, Proudfoot Amanda E I, Handel Tracy

Abstract excerpt

Chemokines orchestrate the migration of leukocytes in the context of homeostasis and inflammation. In addition to interactions of chemokines with receptors on migrating cells, these processes require interactions of chemokines with glycosaminoglycans (GAGs) for cell surface localization. Most chemokines are basic proteins with Arg/Lys/His residue clusters functioning as recognition epitopes for GAGs. In this...

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Identifiers

PMID: 20363748
DOI: 10.1074/jbc.M109.082552
PMCID: PMC2878535

Genes

CXCL11
CXCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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