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Article

Functional divergence between 2 chemokines is conferred by single amino acid change.

Blood - 25 Nov 2010

Dubrac Alexandre, Quemener Cathy, Lacazette Eric, Lopez Fréderic, Zanibellato Catherine, Wu Wen-Guey, Bikfalvi Andréas, Prats Hervé

Abstract excerpt

CXCL4 and CXCL4L1 are 2 closely related CXC chemokines that exhibit potent antiangiogenic activity. Because interactions with glycosaminoglycans play a crucial role in chemokines activity, we determined the binding parameters of CXCL4 and CXCL4L1 for heparin, heparan sulfate, and chondroitin sulfate B. We further demonstrated that the Leu67/His67 substitution is critical for the decrease in glycan binding of...

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PMID: 20688960
DOI: 10.1182/blood-2010-03-274852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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