Article
Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo.
The Journal of biological chemistry - 21 May 2004
Lau Elaine K, Paavola Chad D, Johnson Zoë, Gaudry Jean-Philippe, Geretti Elena, Borlat Frédéric, Kungl Andreas J, Proudfoot Amanda E, Handel Tracy M
Abstract excerpt
In a recent study, we demonstrated that glycosaminoglycan (GAG) binding and oligomerization are essential for the in vivo function of the chemokines MCP-1/CCL2, RANTES/CCL5, and MIP-1beta/CCL4 (1). Binding to the GAG chains of cell surface proteoglycans is thought to facilitate the formation of high localized concentrations of chemokines, which in turn provide directional signals for leukocyte migration. To...
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