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Article

Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo.

The Journal of biological chemistry - 21 May 2004

Lau Elaine K, Paavola Chad D, Johnson Zoë, Gaudry Jean-Philippe, Geretti Elena, Borlat Frédéric, Kungl Andreas J, Proudfoot Amanda E, Handel Tracy M

Abstract excerpt

In a recent study, we demonstrated that glycosaminoglycan (GAG) binding and oligomerization are essential for the in vivo function of the chemokines MCP-1/CCL2, RANTES/CCL5, and MIP-1beta/CCL4 (1). Binding to the GAG chains of cell surface proteoglycans is thought to facilitate the formation of h...

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Source

Identifiers

PMID: 15033992
DOI: 10.1074/jbc.M311224200

Genes

CCL2
CCL4
CCL5
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15033992-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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