Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CXCR3 and heparin binding sites of the chemokine IP-10 (CXCL10).

The Journal of biological chemistry - 9 May 2003

Campanella Gabriele S V, Lee Elizabeth M J, Sun Jieti, Luster Andrew D

Abstract excerpt

The chemokine IP-10 (interferon-inducible protein of 10 kDa, CXCL10) binds the G protein-coupled receptor CXCR3, which is found mainly on activated T cells and NK cells, and plays an important role in Th1-type inflammatory diseases. IP-10 also binds to glycosaminoglycans (GAGs), an interaction thought to be important for its sequestration on endothelial and other cells. In this study, we performed an extensive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine CXCL10
Share to Chemokines, CXC
Share to Chemotaxis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heparin

Share to Mutagenesis, Site-Directed

Share to Protein Conformation

Share to Receptors, Chemokine

Share to Receptors, CXCR3

Source

Identifiers

PMID: 12571234
DOI: 10.1074/jbc.M212077200

Genes

CXCR3
CXCL10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CXCR3 and heparin binding sites of the chemokine IP-10 (CXCL10).PMID 12571234Read ↗

Characterization of the chemokine CXCL11-heparin interaction suggests two different affinities for glycosaminoglycans.Semantic proximity Read ↗

Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function.Semantic proximity Read ↗

C-terminal truncation of CXCL10 attenuates inflammatory activity but retains angiostatic propertiesSemantic proximity Read ↗

The negative charge of the 343 site is essential for maintaining physiological functions of CXCR4.Semantic proximity Read ↗

Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycansSemantic proximity Read ↗

Structural and functional characterization of human CXCR4 as a chemokine receptor and HIV-1 co-receptor by mutagenesis and molecular modeling studies.Semantic proximity Read ↗

Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions.Semantic proximity Read ↗

Galectin-3 binds to the RGD-binding site in a glycan-independent manner and to the allosteric site and activates integrins αvβ3, αIIbβ3, and α5β1Semantic proximity Read ↗

The angiostatic activity of interferon-inducible protein-10/CXCL10 in human melanoma depends on binding to CXCR3 but not to glycosaminoglycan.Semantic proximity Read ↗

Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation.Semantic proximity Read ↗

The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune DiseasesSemantic proximity Read ↗

Differential activity and selectivity of N-terminal modified CXCL12 chemokines at the CXCR4 and ACKR3 receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.