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Article

Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions.

Scientific reports - 14 Sept 2016

Sawant Kirti V, Poluri Krishna Mohan, Dutta Amit K, Sepuru Krishna Mohan, Troshkina Anna, Garofalo Roberto P, Rajarathnam Krishna

Abstract excerpt

The chemokine CXCL1/MGSA plays a pivotal role in the host immune response by recruiting and activating neutrophils for microbial killing at the tissue site. CXCL1 exists reversibly as monomers and dimers, and mediates its function by binding glycosaminoglycans (GAG) and CXCR2 receptor. We recently showed that both monomers and dimers are potent CXCR2 agonists, the dimer is the high-affinity GAG ligand, lysine and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Interleukin-8B

Source

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Identifiers

PMID: 27625115
DOI: 10.1038/srep33123
PMCID: PMC5021969

Genes

CXCL1
CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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