Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans

Abstract excerpt

Chemokine driven leukocyte recruitment is a key component of the immune response and is central to a wide range of diseases. However, there has yet to be a clinically successful therapeutic approach that targets the chemokine system during inflammatory disease; possibly due to the supposed redundancy of the chemokine system. A range of recent studies have demonstrated that the chemokine system is in fact based on...

Topics

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• Cell Adhesion Molecules Research
• Cell Movement
• Chemokine receptors and signaling
• Chemokines
• Immune Response and Inflammation
• Immunotherapy and Immune Responses
• Receptors, Chemokine
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

8b2b88c8-6a04-5671-a0fe-29872d1bf945

DOI

10.1101/2022.09.20.508420