Article
The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity.
The Journal of biological chemistry - 6 Apr 2001
Proudfoot A E, Fritchley S, Borlat F, Shaw J P, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham P R, Wells T N
Abstract excerpt
The chemokine RANTES (regulated on activation normal T cell expressed and secreted; CCL5) binds selectively to glycosaminoglycans (GAGs) such as heparin, chondroitin sulfate, and dermatan sulfate. The primary sequence of RANTES contains two clusters of basic residues, (44)RKNR(47) and (55)KKWVR(59). The first is a BBXB motif common in heparin-binding proteins, and the second is located in the loop directly...
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