Article

C-terminal truncation of CXCL10 attenuates inflammatory activity but retains angiostatic properties

2023-07-10

Abstract excerpt

<h4>ABSTRACT</h4> Interferon-γ-inducible protein of 10 kDa (IP-10/CXCL10) is a dual-function CXC chemokine that coordinates chemotaxis of activated T cells and natural killer (NK) cells via interaction with its G protein-coupled receptor (GPCR), CXC chemokine receptor 3 (CXCR3). As a consequence of natural posttranslational modifications, human CXCL10 exhibits a high degree of structural and functional heterogene...

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Literature Corpus work: ca6d547a-6efc-579b-aef0-1f576c0c597d
DOI: 10.1101/2023.07.10.548382

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