Article
Evidence for polygenic susceptibility to multiple sclerosis--the shape of things to come.
American journal of human genetics - 9 Apr 2010
Bush William S, Sawcer Stephen J, de Jager Philip L, Oksenberg Jorge R, McCauley Jacob L, Pericak-Vance Margaret A, Haines Jonathan L
Abstract excerpt
It is well established that the risk of developing multiple sclerosis is substantially increased in the relatives of affected individuals and that most of this increase is genetically determined. The observed pattern of familial recurrence risk has long suggested that multiple variants are involved, but it has proven difficult to identify individual risk variants and little has been established about the genetic...
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