Genetics of Multiple Sclerosis: An Overview and New Directions.

doi:10.1101/cshperspect.a028951

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Article

Genetics of Multiple Sclerosis: An Overview and New Directions.

Cold Spring Harbor perspectives in medicine - 2 Jul 2018

Patsopoulos Nikolaos A

Abstract excerpt

The contribution of genetic inheritance in multiple sclerosis was established early on. Although multiple sclerosis is not a Mendelian disease, its incidence and prevalence is higher in family members of affected individuals compared with the general population. Throughout the last decade, several small studies failed to identify any robust genetic associations besides the classic associations in the major...

Topics

Environmental Health
Genetic Heterogeneity
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Humans
Multiple Sclerosis
Pedigree
Phenotype
Risk Factors

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Identifiers

PMID: 29440325
DOI: 10.1101/cshperspect.a028951
PMCID: PMC6027932

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