Article
Reworking GWAS Data to Understand the Role of Nongenetic Factors in MS Etiopathogenesis.
Genes - 14 Jan 2020
Mechelli Rosella, Umeton Renato, Manfrè Grazia, Romano Silvia, Buscarinu Maria Chiara, Rinaldi Virginia, Bellucci Gianmarco, Bigi Rachele, Ferraldeschi Michela, Salvetti Marco, Ristori Giovanni
Abstract excerpt
Genome-wide association studies have identified more than 200 multiple sclerosis (MS)-associated loci across the human genome over the last decade, suggesting complexity in the disease etiology. This complexity poses at least two challenges: the definition of an etiological model including the impact of nongenetic factors, and the clinical translation of genomic data that may be drivers for new druggable targets....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.