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Article

Sustained β-catenin activity in dermal fibroblasts promotes fibrosis by up-regulating expression of extracellular matrix protein-coding genes.

The Journal of pathology - 1 Apr 2015

Hamburg-Shields Emily, DiNuoscio Gregg J, Mullin Nathaniel K, Lafyatis Robert, Atit Radhika P

Abstract excerpt

Fibrosis is an end-stage response to tissue injury that is associated with loss of organ function as a result of excess extracellular matrix (ECM) production by fibroblasts. In skin, pathological fibrosis is evident during keloid scar formation, systemic sclerosis (SSc) and morphea. Dermal fibroblasts in these fibrotic diseases exhibit increased Wnt/β-catenin signalling, a pathway that is sufficient to cause...

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PMID: 25385294
DOI: 10.1002/path.4481
PMCID: PMC4357547

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