Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted Deletion of the SPARC Gene Accelerates Disc Degeneration in the Aging Mouse

6 May 2005

Abstract excerpt

SPARC (secreted protein, acidic, and rich in cysteine) is a matricellular protein that is present in the intervertebral disc; in man, levels of SPARC decrease with aging and degeneration. In this study, we asked whether targeted deletion of SPARC in the mouse influenced disc morphology. SPARC-null and wild-type (WT) mice were studied at 0.3-21 months of age. Radiologic examination of spines from 2-month-old...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Dental Protein Studies
Share to Bone health and treatments
Share to Bone Metabolism and Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15879573
DOI: 10.1369/jhc.5a6687.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted Deletion of the SPARC Gene Accelerates Disc Degeneration in the Aging MousePMID 15879573Read ↗

Pleiotropic roles of the matricellular protein Sparc in tendon maturation and ageingSemantic proximity Read ↗

Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc aging.Semantic proximity Read ↗

DNA Methylation of SPARC and Chronic Low Back PainSemantic proximity Read ↗

PRIMUS: Comprehensive proteomics of mouse intervertebral discs that inform novel biology and relevance to human disease modellingSemantic proximity Read ↗

Impaired Intervertebral Disc Development and Premature Disc Degeneration in Mice With Notochord‐Specific Deletion of CCN2Semantic proximity Read ↗

Load-induced regulation of tendon homeostasis by SPARC, a genetic predisposition factor for tendon and ligament injuries.Semantic proximity Read ↗

SPARC/osteonectin in mineralized tissue.Semantic proximity Read ↗

Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization.Semantic proximity Read ↗

Neuroimmune changes underscore pain-associated behaviors and disc herniations in SM/J miceSemantic proximity Read ↗

The impact of SPARC on age-related cardiac dysfunction and fibrosis in DrosophilaSemantic proximity Read ↗

Klotho mutation does not accelerate intervertebral disc aging in mice.Semantic proximity Read ↗

Histological and reference system for the analysis of mouse intervertebral discSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.