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Article

Phenotypic Characterization of Transgenic Mice Expressing Human IGFBP-5.

International journal of molecular sciences - 30 Dec 2020

Nguyen Xinh-Xinh, Sanderson Matthew, Helke Kristi, Feghali-Bostwick Carol

Abstract excerpt

Pulmonary fibrosis is one of the important causes of morbidity and mortality in fibroproliferative disorders such as systemic sclerosis (SSc) and idiopathic pulmonary fibrosis (IPF). Insulin-like growth factor binding protein-5 (IGFBP-5) is a conserved member of the IGFBP family of proteins that is overexpressed in SSc and IPF lung tissues. In this study, we investigated the functional role of IGFBP-5 in the...

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Identifiers

PMID: 33396956
DOI: 10.3390/ijms22010335
PMCID: PMC7795366

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