Article
Development of primer-special TaqMan PCR: a novel SNP detection method to detect CYP2C9 3 in South Chinese.
Molecular diagnosis & therapy - 1 Apr 2010
Qiu Geng, Wang Ying, Fu Rong, He Yunshao, Chen Zirong, Chen Jiachang
Abstract excerpt
BACKGROUND: CYP2C9 3 (1075A/C) is an inherited single nuclear polymorphism (SNP) of cytochrome P450 (CYP) 2C9, which affects the activity of the enzyme. In vitro studies with several drugs have indicated that the CYP2C9 3 variant has an impaired capacity for drug metabolism. Therefore an efficient detection assay for this mutation may be important for clinical dose adjustment. OBJECTIVE: The aim of this work was...
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