Article
Mutation-sensitive molecular switch method to detect CES1A2 mutation in the Chinese Han and Yao populations.
Genetic testing and molecular biomarkers - 1 Sept 2011
Ding Xiao-Liang, Deng Yang-Lin, Zhang Jun, Miao Li-Yan
Abstract excerpt
Carboxylesterase 1 (CES1) is involved in the metabolic activation of a variety of prodrugs into active derivatives and plays an important role in pharmacokinetics and pharmacodynamics. A single-nucleotide polymorphism, A(-816)C, of the CES1A2 gene has been shown to enhance transcription efficiency and increase enzyme activity. The aim of this study was to develop an easy method to detect this polymorphism. For...
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