Article
The hydrophobic core of the Sec61 translocon defines the hydrophobicity threshold for membrane integration.
Molecular biology of the cell - 15 May 2010
Junne Tina, Kocik Lucyna, Spiess Martin
Abstract excerpt
The Sec61 translocon mediates the translocation of proteins across the endoplasmic reticulum membrane and the lateral integration of transmembrane segments into the lipid bilayer. The structure of the idle translocon is closed by a lumenal plug domain and a hydrophobic constriction ring. To test the function of the apolar constriction, we have mutated all six ring residues of yeast Sec61p to more hydrophilic,...
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