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Article

Dynamics of SecY translocons with translocation-defective mutations.

Structure (London, England : 1993) - 14 Jul 2010

Bondar Ana-Nicoleta, del Val Coral, Freites J Alfredo, Tobias Douglas J, White Stephen H

Abstract excerpt

The SecY/Sec61 translocon complex, located in the endoplasmic reticulum membrane of eukaryotes (Sec61) or the plasma membrane of prokaryotes (SecY), mediates the transmembrane secretion or insertion of nascent proteins. Mutations that permit the secretion of nascent proteins with defective signal sequences (Prl-phenotype), or interfere with the transmembrane orientation of newly synthesized protein segments, can...

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Identifiers

PMID: 20637421
DOI: 10.1016/j.str.2010.04.010
PMCID: PMC2909450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dynamics of SecY translocons with translocation-defective mutations.PMID 20637421Read ↗

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Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes.Semantic proximity Read ↗

The SecY translocation complex: convergence of genetics and structure.Semantic proximity Read ↗

Translocation of proteins through the Sec61 and SecYEG channels.Semantic proximity Read ↗

Quaternary dynamics of the SecA motor drive translocase catalysis.Semantic proximity Read ↗

The hydrophobic core of the Sec61 translocon defines the hydrophobicity threshold for membrane integration.Semantic proximity Read ↗

Mechanisms of SecM-mediated stalling in the ribosome.Semantic proximity Read ↗

Membrane protein sequence features direct post-translational insertionSemantic proximity Read ↗

Features of membrane protein sequence direct post-translational insertion.Semantic proximity Read ↗

A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function.Semantic proximity Read ↗

The PrlA and PrlG phenotypes are caused by a loosened association among the translocase SecYEG subunits.Semantic proximity Read ↗

Dynamic action of the Sec machinery during initiation, protein translocation and termination.Semantic proximity Read ↗

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