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Article

Functional asymmetry within the Sec61p translocon.

Proceedings of the National Academy of Sciences of the United States of America - 19 Nov 2013

Demirci Erhan, Junne Tina, Baday Sefer, Bernèche Simon, Spiess Martin

Abstract excerpt

The Sec61 translocon forms a pore to translocate polypeptide sequences across the membrane and offers a lateral gate for membrane integration of hydrophobic (H) segments. A central constriction of six apolar residues has been shown to form a seal, but also to determine the hydrophobicity threshold for membrane integration: Mutation of these residues in yeast Sec61p to glycines, serines, aspartates, or lysines...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24191046
DOI: 10.1073/pnas.1318432110
PMCID: PMC3839696

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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