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Article

Polarity and charge of the periplasmic loop determine the YidC and sec translocase requirement for the M13 procoat lep protein.

The Journal of biological chemistry - 10 Jan 2014

Soman Raunak, Yuan Jijun, Kuhn Andreas, Dalbey Ross E

Abstract excerpt

During membrane biogenesis, the M13 procoat protein is inserted into the lipid bilayer in a strictly YidC-dependent manner with both the hydrophobic signal sequence and the membrane anchor sequence promoting translocation of the periplasmic loop via a hairpin mechanism. Here, we find that the translocase requirements can be altered for PClep in a predictable manner by changing the polarity and charge of the...

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Source

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Identifiers

PMID: 24275657
DOI: 10.1074/jbc.M113.522250
PMCID: PMC3887171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polarity and charge of the periplasmic loop determine the YidC and sec translocase requirement for the M13 procoat lep protein.PMID 24275657Read ↗

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