Article
Preserving the membrane barrier for small molecules during bacterial protein translocation.
Nature - 12 May 2011
Park Eunyong, Rapoport Tom A
Abstract excerpt
Many proteins are translocated through the SecY channel in bacteria and archaea and through the related Sec61 channel in eukaryotes. The channel has an hourglass shape with a narrow constriction approximately halfway across the membrane, formed by a pore ring of amino acids. While the cytoplasmic cavity of the channel is empty, the extracellular cavity is filled with a short helix called the plug, which moves out...
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