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Article

MEK1 and AKT2 mutations in Japanese lung cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 May 2010

Sasaki Hidefumi, Hikosaka Yu, Kawano Osamu, Moriyama Satoru, Yano Motoki, Fujii Yoshitaka

Abstract excerpt

BACKGROUND: Recently, to identify potential somatic mutations in genes of epidermal growth factor receptor (EGFR) signaling pathway, MEK1 gene mutation at exon 2 and mutation of the AKT2 (v-akt murine thymoma viral oncogene homologue 2) gene at kinase domain have been reported in non-small cell lung cancer. METHODS: We investigated the MEK1 mutation (n = 280) and AKT2 mutation (n = 273) in surgically treated...

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Source

Identifiers

PMID: 20354455
DOI: 10.1097/JTO.0b013e3181d35236

Genes

AKT2
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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