Article
Analysis of ERBB4 mutations and expression in japanese patients with lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Nov 2010
Tomizawa Kenji, Suda Kenichi, Onozato Ryoichi, Kuwano Hiroyuki, Yatabe Yasushi, Mitsudomi Tetsuya
Abstract excerpt
Only the kinase domain of ERBB4 has been analyzed in East Asian populations, but a recent large-scale mutation analysis has indicated a higher incidence of mutations in the extracellular domain. Mutations in the extracellular and kinase domains of ERBB4 were examined by direct sequencing in 72 patients with primary lung cancer and 8 cell lines. In addition, ERBB4 expression was determined in 60 patients by...
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