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Article

Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma.

Cancer research - 15 Jul 2008

Marks Jenifer L, Gong Yixuan, Chitale Dhananjay, Golas Ben, McLellan Michael D, Kasai Yumi, Ding Li, Mardis Elaine R, Wilson Richard K, Solit David, Levine Ross, Michel Kathrin, Thomas Roman K, Rusch Valerie W, Ladanyi Marc, Pao William

Abstract excerpt

Genetic lesions affecting a number of kinases and other elements within the epidermal growth factor receptor (EGFR) signaling pathway have been implicated in the pathogenesis of human non-small-cell lung cancer (NSCLC). We performed mutational profiling of a large cohort of lung adenocarcinomas t...

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Share to Adenocarcinoma
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ErbB Receptors

Share to Gene Expression Regulation, Enzymologic

Share to Gene Expression Regulation, Neoplastic

Share to Lung Neoplasms

Share to MAP Kinase Kinase 1

Share to Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 18632602
DOI: 10.1158/0008-5472.CAN-08-0099
PMCID: PMC2586155

Genes

EGFR
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18632602-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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