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Article

LKB1 gene mutations in Japanese lung cancer patients.

Cancer science - 1 Nov 2007

Onozato Ryoichi, Kosaka Takayuki, Achiwa Hiroyuki, Kuwano Hiroyuki, Takahashi Takashi, Yatabe Yasushi, Mitsudomi Tetsuya

Abstract excerpt

Mutation of the LKB1 gene (also known as STK11) is regarded as a cause of Peutz-Jeghers syndrome. In Caucasian patients, LKB1 somatic mutations occur in approximately one-third of lung adenocarcinomas. The aim of the present study was to examine the LKB1 gene in Japanese patients with lung cancer and to evaluate its clinical and pathological implications. We sequenced the LKB1 gene in 22 lung cancer cell lines...

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Source

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Identifiers

PMID: 17711506
DOI: 10.1111/j.1349-7006.2007.00585.x
PMCID: PMC11158871

Genes

EGFR
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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