Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ERBB2 kinase domain mutation in the lung squamous cell carcinoma.

Cancer letters - 8 Jun 2006

Lee Jong Woo, Soung Young Hwa, Kim Su Young, Nam Suk Woo, Park Won Sang, Wang Young Pil, Jo Keon Hyun, Moon Seok Whan, Song Sang Yong, Lee Jung Young, Yoo Nam Jin, Lee Sug Hyung

Abstract excerpt

Mounting evidence exists that the activation of proto-oncogene by somatic mutation plays an important roles in the development of human cancers. Recent reports revealed that the kinase domain of ERBB2 gene, a proto-oncogene, is somatically mutated in the lung adenocarcinomas, suggesting the mutated ERBB2 gene may act as an oncogene in human cancers. The purpose of this was to see whether the ERBB2 kinase domain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Adenosquamous
Share to Carcinoma, Large Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung

Share to Carcinoma, Squamous Cell

Share to Gene Expression Regulation, Neoplastic

Share to Polymorphism, Single-Stranded Conformational

Share to Proto-Oncogene Mas

Share to Receptor, ErbB-2

Source

Identifiers

PMID: 16029927
DOI: 10.1016/j.canlet.2005.05.026

Genes

ERBB2
BRAF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ERBB2 kinase domain mutation in the lung squamous cell carcinoma.PMID 16029927Read ↗

Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.Semantic proximity Read ↗

Lung adenocarcinoma harboring mutations in the ERBB2 kinase domain.Semantic proximity Read ↗

EGFR, ERBB2, and KRAS mutations in Korean non-small cell lung cancer patients.Semantic proximity Read ↗

ERBB2 mutation landscape in non-small cell lung cancer patients in Northeast China.Semantic proximity Read ↗

Somatic mutations of the ERBB4 kinase domain in human cancers.Semantic proximity Read ↗

Mutational landscape and characteristics of ERBB2 in non-small cell lung cancer.Semantic proximity Read ↗

Somatic mutations of the HER2 kinase domain in lung adenocarcinomas.Semantic proximity Read ↗

Clinical and molecular characteristics of Chinese non-small cell lung cancer patients with ERBB2 transmembrane domain mutations.Semantic proximity Read ↗

EGFR and erbB2 mutation status in Japanese lung cancer patientsSemantic proximity Read ↗

ErbBs in lung cancer.Semantic proximity Read ↗

Abnormalities of epidermal growth factor receptor in lung squamous-cell carcinomas, adenosquamous carcinomas, and large-cell carcinomas: tyrosine kinase domain mutations are not rare in tumors with an adenocarcinoma component.Semantic proximity Read ↗

Functional Analyses of Mutations in Receptor Tyrosine Kinase Genes in Non-Small Cell Lung Cancer: Double-Edged Sword of DDR2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.