Article
Genetic variation in cholinergic muscarinic-2 receptor gene modulates M2 receptor binding in vivo and accounts for reduced binding in bipolar disorder.
Molecular psychiatry - 1 Apr 2011
Cannon D M, Klaver J K, Gandhi S K, Solorio G, Peck S A, Erickson K, Akula N, Savitz J, Eckelman W C, Furey M L, Sahakian B J, McMahon F J, Drevets W C
Abstract excerpt
Genetic variation in the cholinergic muscarinic-2 (M(2)) receptor gene (CHRM2) has been associated with the risk for developing depression. We previously reported that M(2)-receptor distribution volume (V(T)) was reduced in depressed subjects with bipolar disorder (BD) relative to depressed subjects with major depressive disorder (MDD) and healthy controls (HCs). In this study, we investigated the effects of six...
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