Article
Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome.
Human molecular genetics - 1 Sept 2004
Wang Jen C, Hinrichs Anthony L, Stock Heather, Budde John, Allen Rebecca, Bertelsen Sarah, Kwon Jennifer M, Wu William, Dick Danielle M, Rice John, Jones Kevin, Nurnberger John I, Tischfield Jay, Porjesz Bernice, Edenberg Howard J, Hesselbrock Victor, Crowe Ray, Schuckit Mark, Begleiter Henri, Reich Theodore, Goate Alison M, Bierut Laura J
Abstract excerpt
Several correlated phenotypes, alcohol dependence, major depressive syndrome, and an endophenotype of electrophysiological measurements, event-related oscillations (EROs), have demonstrated linkage on the long arm of chromosome 7. Recently, we reported both linkage and association between polymorphisms in the gene encoding the muscarinic acetylcholine receptor M2 (CHRM2) and EROs. In this study, we evaluated...
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