Article
Association of serotonin 5-HT2A receptor binding and the T102C polymorphism in depressed and healthy Caucasian subjects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2005
Khait Vadim D, Huang Yung-yu, Zalsman Gil, Oquendo Maria A, Brent David A, Harkavy-Friedman Jill M, Mann J John
Abstract excerpt
Serotonin 5-HT2A receptor (5-HT2A) binding is reported to be altered in individuals with suicidal behavior, mood disorders, and aggressive-impulsive traits. Genetic association with major depression, suicidal behavior, and aggressive-impulsive traits has not been established. This study examines the possible association of the 5-HT2A gene C102T polymorphism with the receptor binding kinetics, and clinical overt...
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