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Article

Familial risk for major depression is associated with lower striatal 5-HT₄ receptor binding.

The international journal of neuropsychopharmacology - 31 Oct 2014

Madsen Karine, Torstensen Eva, Holst Klaus K, Haahr Mette E, Knorr Ulla, Frokjaer Vibe G, Brandt-Larsen Malene, Iversen Pernille, Fisher Patrick M, Knudsen Gitte M

Abstract excerpt

BACKGROUND: The 5-HT4 receptor provides a novel potential target for antidepressant treatment. No studies exist to elucidate the 5-HT4 receptor's in vivo distribution in the depressed state or in populations that may display trait markers for major depression disorder (MDD). The aim of this study was to determine whether familial risk for MDD is associated with cerebral 5-HT4 receptor binding as measured with...

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Identifiers

PMID: 25522384
DOI: 10.1093/ijnp/pyu034
PMCID: PMC4368872

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