Article
CHRNA7 haplotypes are associated with impaired attention in euthymic bipolar disorder.
Journal of affective disorders - 1 Sept 2011
Ancín I, Cabranes J A, Santos J L, Sánchez-Morla E, Vázquez-Álvarez B, Rodríguez-Moya L, Pousada-Casal A, Fernández C, Aparicio A, Barabash A
Abstract excerpt
BACKGROUND: Bipolar disorder (BD) patients show a deficit in sustained attention during euthymic periods. This deficit may be relevant for genetic studies in these patients. The α7 cholinergic receptor plays an important role in attentional deficit in humans and animal models. Moreover, there is evidence suggesting the role of the alpha 7 nicotinic cholinergic receptor subunit gene (CHRNA7) in BD susceptibility....
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