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Article

Association of the muscarinic cholinergic 2 receptor (CHRM2) gene with major depression in women.

American journal of medical genetics - 8 Jul 2002

Comings David E, Wu Sujihan, Rostamkhani M, McGue Matt, Iacono William G, MacMurray James P

Abstract excerpt

Cholinergic neurons have been implicated in depression and in the disorders of REM sleep in depression. We examined a common A-> T 1890 polymorphism in the 3' UTR of the cholinergic muscarinic receptor 2 (CHRM2) gene. There was a significant increase in the frequency of 11 homozygotes in 126 women with major depression (43.7%) compared to 304 women without major depression (25.7%), P =.001. There was no increase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12116189
DOI: 10.1002/ajmg.10406

Genes

CHRM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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