Article
Hrp48 attenuates Sxl expression to allow for proper notch expression and signaling in wing development.
Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 2010
Suissa Yaron, Kalifa Yossi, Dinur Tama, Graham Patricia, Deshpande Girish, Schedl Paul, Gerlitz Offer
Abstract excerpt
Different signaling pathways are deployed in specific developmental contexts to generate sexually dimorphic traits. Recently, Sex-lethal (Sxl), the female determinant in Drosophila melanogaster, was shown to down-regulate Notch (N) signaling to accomplish sex-specific patterning. Paradoxically, however, both Sxl and N are ubiquitously expressed in all of the female cells. This raises a key question as to how,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.