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Article

An inducible RNA interference system for the functional dissection of mouse embryogenesis.

Nucleic acids research - 1 Jun 2010

Vidigal Joana A, Morkel Markus, Wittler Lars, Brouwer-Lehmitz Antje, Grote Phillip, Macura Karol, Herrmann Bernhard G

Abstract excerpt

Functional analysis of multiple genes is key to understanding gene regulatory networks controlling embryonic development. We have developed an integrated vector system for inducible gene silencing by shRNAmir-mediated RNA interference in mouse embryos, as a fast method for dissecting mammalian gene function. For validation of the vector system, we generated mutant phenotypes for Brachyury, Foxa2 and Noto,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 20350929
DOI: 10.1093/nar/gkq199
PMCID: PMC2887975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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