Article
Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos.
Scientific reports - 21 Nov 2016
Cui Wei, Dai Xiangpeng, Marcho Chelsea, Han Zhengbin, Zhang Kun, Tremblay Kimberly D, Mager Jesse
Abstract excerpt
With readily available transcriptome-wide data, understanding the role of each expressed gene is an essential next step. Although RNAi technologies allow for genome-wide screens in cell culture, these approaches cannot replace strategies for discovery in the embryo. Here we present, for the first time, a knockdown screen in mouse preimplantation embryos. Early mammalian development encompasses dynamic cellular,...
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