Article
Analysis of mouse embryonic patterning and morphogenesis by forward genetics.
Proceedings of the National Academy of Sciences of the United States of America - 26 Apr 2005
García-García María J, Eggenschwiler Jonathan T, Caspary Tamara, Alcorn Heather L, Wyler Michael R, Huangfu Danwei, Rakeman Andrew S, Lee Jeffrey D, Feinberg Evan H, Timmer John R, Anderson Kathryn V
Abstract excerpt
Many aspects of the genetic control of mammalian embryogenesis cannot be extrapolated from other animals. Taking a forward genetic approach, we have induced recessive mutations by treatment of mice with ethylnitrosourea and have identified 43 mutations that affect early morphogenesis and patterning, including 38 genes that have not been studied previously. The molecular lesions responsible for 14 mutations were...
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