Article
A 2cM genome-wide scan of European Holstein cattle affected by classical BSE.
BMC genetics - 29 Mar 2010
Murdoch Brenda M, Clawson Michael L, Laegreid William W, Stothard Paul, Settles Matthew, McKay Stephanie, Prasad Aparna, Wang Zhiquan, Moore Stephen S, Williams John L
Abstract excerpt
BACKGROUND: Classical bovine spongiform encephalopathy (BSE) is an acquired prion disease that is invariably fatal in cattle and has been implicated as a significant human health risk. Polymorphisms that alter the prion protein of sheep or humans have been associated with variations in transmissible spongiform encephalopathy susceptibility or resistance. In contrast, there is no strong evidence that...
Topics
- Animals
- Case-Control Studies
- Cattle
- Encephalopathy, Bovine Spongiform
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- INDEL Mutation