Article
Short communication: Allele, genotype, and haplotype data for bovine spongiform encephalopathy-resistance polymorphisms from healthy US Holstein cattle.
Journal of dairy science - 1 Jan 2008
Brunelle B W, Kehrli M E, Stabel J R, Spurlock D Moody, Hansen L B, Nicholson E M
Abstract excerpt
Bovine spongiform encephalopathy (BSE) is a neurodegenerative disease of cattle caused by abnormally folded prion proteins. Two regulatory region polymorphisms in the bovine prion gene are associated with resistance to classical BSE disease: a 23-bp region in the promoter that contains a binding site for the repressor protein RP58, and a 12-bp region in intron 1 that has a binding site for the transcription...
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