Article
Prion gene haplotypes of U.S. cattle.
BMC genetics - 8 Nov 2006
Clawson Michael L, Heaton Michael P, Keele John W, Smith Timothy P L, Harhay Gregory P, Laegreid William W
Abstract excerpt
BACKGROUND: Bovine spongiform encephalopathy (BSE) is a fatal neurological disorder characterized by abnormal deposits of a protease-resistant isoform of the prion protein. Characterizing linkage disequilibrium (LD) and haplotype networks within the bovine prion gene (PRNP) is important for 1) testing rare or common PRNP variation for an association with BSE and 2) interpreting any association of PRNP alleles...
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