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Article

Genome-wide scan identifies loci associated with classical BSE occurrence.

PloS one - 1 Jan 2011

Murdoch Brenda M, Murdoch Gordon K, Settles Matthew, McKay Stephanie, Williams John L, Moore Stephen S

Abstract excerpt

Classical bovine spongiform encephalopathy (BSE) is an acquired prion disease that is invariably fatal in cattle and has been implicated as a significant human health risk. Sequence variations in the coding region of the prion gene (PRNP) have been associated with acquired transmissible spongiform encephalopathy (TSE) susceptibility in mammals; however, this is not the case in cattle. It has been hypothesized...

Topics

Animals
Cattle
Encephalopathy, Bovine Spongiform
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Polymorphism, Single Nucleotide
Quality Control

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22073200
DOI: 10.1371/journal.pone.0026819
PMCID: PMC3208576

Genes

PRNP

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