Article
The identification of candidate genes and SNP markers for classical bovine spongiform encephalopathy susceptibility.
Prion - 1 Jan 2000
Thomson Jennifer M, Bowles Victoria, Choi Jung-Woo, Basu Urmila, Meng Yan, Stothard Paul, Moore Stephen
Abstract excerpt
Classical bovine spongiform encephalopathy is a transmissible prion disease that is fatal to cattle and is a human health risk due to its association with a strain of Creutzfeldt-Jakob disease (vCJD). Mutations to the coding region of the prion gene (PRNP) have been associated with susceptibility to transmissible spongiform encephalopathies in mammals including bovines and humans. Additional loci such as the...
Topics
- Alleles
- Animals
- Cattle
- Chromosomes, Mammalian
- Encephalopathy, Bovine Spongiform
- Genetic Association Studies
- Genetic Markers
- Genetic Predisposition to Disease
- Genome
- Membrane Proteins
- Polymorphism, Single Nucleotide
- Prions