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Article

Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya.

Malaria journal - 29 Mar 2010

Zhang Lyna, Prather Donald, Vanden Eng Jodi, Crawford Sara, Kariuki Simon, ter Kuile Feiko, Terlouw Dianne, Nahlen Bernard, Lal Altaf A, Slutsker Laurence, Udhayakumar Venkatachalam, Shi Ya Ping

Abstract excerpt

BACKGROUND: Malarial anaemia is characterized by destruction of malaria infected red blood cells and suppression of erythropoiesis. Interleukin 12 (IL12) significantly boosts erythropoietic responses in murine models of malarial anaemia and decreased IL12 levels are associated with severe malarial anaemia (SMA) in children. Based on the biological relevance of IL12 in malaria anaemia, the relationship between...

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Identifiers

PMID: 20350312
DOI: 10.1186/1475-2875-9-87
PMCID: PMC2858737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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