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Article

The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice.

Immunology letters - 15 Jun 2010

van Dop Willemijn A, Marengo Stefano, te Velde Anje A, Ciraolo Elisa, Franco Irene, ten Kate Fiebo J, Boeckxstaens Guy E, Hardwick James C, Hommes Daan W, Hirsch Emilio, van den Brink Gijs R

Abstract excerpt

Phosphatidylinositol-3-kinase gamma (PI3Kgamma) is the major PI3K that is activated in response to chemoattractants. It is responsible for the migration of leukocytes from the bloodstream to sites of injury or infection. Constant migration of new leukocytes to the intestinal mucosa may be an important factor in maintenance of inflammation and tissue damage in inflammatory bowel disease (IBD). Reducing this...

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Identifiers

PMID: 20347874
DOI: 10.1016/j.imlet.2010.03.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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