Article
Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2014
Sahin Emine, Haubenwallner Stefan, Kuttke Mario, Kollmann Isabella, Halfmann Angela, Dohnal Alexander M, Dohnal Alexander B, Chen Li, Cheng Paul, Hoesel Bastian, Einwallner Elisa, Brunner Julia, Kral Julia B, Schrottmaier Waltraud C, Thell Kathrin, Saferding Victoria, Blüml Stephan, Schabbauer Gernot
Abstract excerpt
The activation of innate immune cells triggers numerous intracellular signaling pathways, which require tight control to mount an adequate immune response. The PI3K signaling pathway is intricately involved in innate immunity, and its activation dampens the expression and release of proinflammatory cytokines in myeloid cells. These signaling processes are strictly regulated by the PI3K antagonist, the lipid...
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