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Article

Selective regulation of CD8 effector T cell migration by the p110 gamma isoform of phosphatidylinositol 3-kinase.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2008

Martin Amanda L, Schwartz Matthew D, Jameson Stephen C, Shimizu Yoji

Abstract excerpt

Chemokine-mediated T cell migration is essential to an optimal immune response. The p110gamma isoform of PI3K is activated by G protein-coupled receptors and regulates neutrophil and macrophage chemotaxis. We used p110gamma-deficient mice to examine the role of p110gamma in CD8 T cell migration and activation in response to viral challenge. Naive CD8 T cell migration in response to CCL21 in vitro and trafficking...

Read the complete abstract on PubMed

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Share to CD8-Positive T-Lymphocytes
Share to Chemotaxis, Leukocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphocyte Activation

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Source

Identifiers

PMID: 18250413
DOI: 10.4049/jimmunol.180.4.2081

Genes

CCL21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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