Article
Protection against colitis by CD100-dependent modulation of intraepithelial γδ T lymphocyte function.
Mucosal immunology - 1 Jan 2014
Meehan T F, Witherden D A, Kim C-H, Sendaydiego K, Ye I, Garijo O, Komori H K, Kumanogoh A, Kikutani H, Eckmann L, Havran W L
Abstract excerpt
Intraepithelial γδ T lymphocytes (γδ IEL) have important roles in repair of tissue damage at epithelial sites, such as skin and intestine. Molecules that orchestrate these γδ T-cell functions are not well defined. Recently, interaction of the semaphorin CD100 on skin γδ T cells with plexin B2 on keratinocytes was shown to be important for effective γδ T-cell function in the epidermis, which raised the possibility...
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