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Article

Role of PI3Kδ and PI3Kγ in inflammatory arthritis and tissue localization of neutrophils

15 Apr 2008

Abstract excerpt

The p110delta isoform of class I phosphoinositide 3-kinase (PI3K) plays a major role in B cell receptor signaling, while its p110gamma counterpart is thought to predominate in leukocyte chemotaxis. Consequently, emphasis has been placed on developing PI3Kgamma selective inhibitors to treat disease states that result from inappropriate tissue accumulation of leukocytes. We now demonstrate that PI3Kdelta blockade...

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PMID: 18412166
DOI: 10.1002/eji.200838266

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